L-Arginine Ameliorates Arylesterase/Paraoxonase Activity of Paraoxonase-1 in Hypercholesterolemic Rats
نویسندگان
چکیده
منابع مشابه
PARAOXONASE AND ARYLESTERASE ACTIVITY AMONG HYPERCHOLESTEROLEMIC PATIENTS
Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We exa...
متن کاملInhibition of arginase activity ameliorates L-arginine-induced acute pancreatitis in rats.
OBJECTIVES Intraperitoneal (IP) injection of 3.5 g/kg L-arginine (known to induce acute pancreatitis) in rats will result in much greater increases in serum ornithine versus citrulline concentration (Crit Care Med. 2008;36:2117-2127). These data indicate a major role of arginase in the catabolism of L-arginine. Therefore, we tested the effects of the irreversible arginase inhibitor (+)-S-2-amin...
متن کاملparaoxonase and arylesterase activity among hypercholesterolemic patients
human serum paraoxonase (pon) associated with high density lipoprotein (hdl) , has been postulated to have a role in protecting low-density lipoprotein (ldl) against oxidative damage, which has led to the proposal that pon is an anti-atherogenic and anti-inflammatory enzyme. it has genetic polymorphism at the 191 (r ->q) and two alloenzymes a and b and three phenotypes a, b, and ab. we examined...
متن کاملDietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans.
OBJECTIVES The present study was designed to test the hypothesis that long-term dietary supplementation with the nitric oxide precursor L-arginine would enhance vascular or platelet-derived nitric oxide activity, or both, and thereby inhibit platelet reactivity in hypercholesterolemic humans. BACKGROUND We have shown that reduced vascular activity of nitric oxide in hypercholesterolemic rabbi...
متن کاملL-arginine attenuates platelet reactivity in hypercholesterolemic rabbits.
Platelets are capable of producing nitric oxide (NO) through the L-arginine-NO synthase pathway. Acute exposure to supraphysiological concentrations of L-arginine in vitro increases the production of NO by platelets and is associated with an increase in platelet cyclic GMP (cGMP) levels and a reduction in platelet aggregation. The purpose of this study was to determine if chronic oral administr...
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ژورنال
عنوان ژورنال: Asian Journal of Biochemistry
سال: 2011
ISSN: 1815-9923
DOI: 10.3923/ajb.2011.263.272